This is a preview. Log in through your library . Abstract Characterization of the unfolded state is essential for the understanding of the protein folding reaction. We performed time resolved FRET ...

The dipeptide sequence at the carboxy-terminal of a heavy (μ) chain from a human macroglobulin (IgM) is tyrosylcysteine, although the reverse sequence, cysteinyltyrosine, has not been rigorously ...

How does DNA determine an organism’s characteristics? A process called translation decodes RNA created during transcription, and uses it to create proteins that perform specific cellular functions.

Proteins are the key players that regulate cellular structure and function. DNA, which functions as the blueprint for protein synthesis, is first transcribed into a messenger RNA (mRNA), which is ...

Just as children can strengthen ties between parents, ensuring the family stays together at least until they’re grown, a new study shows nascent polypeptide chains have the inherent ability to ensure ...

For almost 40 years, researchers have been fascinated by the question of how proteins are transported across or are integrated into membranes. Pioneering work by G. Palade 1 demonstrated that in ...

Antibodies are proteins with around 150 kDa molecular weight. They have a similar basic structure comprising of four polypeptide chains held together by disulfide bonds. These four polypeptide chains ...

Proteins are typically encoded by linear strands of messenger RNA (mRNA). These mRNA molecules are translated into polypeptide chains by ribosomes, with each ribosomal read-through of the mRNA ...

Insulin is synthesized in significant quantities only in beta cells in the pancreas. Since it is a protein or a polypeptide structure it is synthesized like most other proteins via transcription and ...

An interdisciplinary team of scientists from Cologne, Heidelberg and Munich have discovered a new function of a well-known enzyme. The signal peptidase complex in the endoplasmic reticulum cleaves ...