The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the ...

Despite its painful sounding name, the stimulator of interferon genes protein, known as STING, is something you want to have around. When active, STING helps ramp up production of inflammatory ...

During the lead optimization phase of biologics drug discovery, researchers use the design, make, test, analyze, and report cycle to make incremental changes to the project’s candidate compounds. As ...

Honghui Hu of Wanhuida Intellectual Property considers the impact of the structure-activity relationship on the inventiveness assessment of pharmaceutical compounds Bayer Intellectual Property GmbH ...