Scientists at Pacific Northwest Research Institute (PNRI) have overturned a long-held belief in genetics: that inheriting two ...

In a groundbreaking study published in the in Proceedings of the National Academy of Sciences (PNAS), scientists at Pacific ...

Scientists found that more than 60% of damaging variant pairs in a metabolic enzyme restored normal activity. The study shows ...

Scientists at Pacific Northwest Research Institute (PNRI) report that pairs of genetic variants previously classified as ...

“We’ve shown that, in many cases, two damaging variants can work together to restore protein function,“ said Aimée Dudley, ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

KJ Muldoon received a groundbreaking new treatment earlier this year. The baby saved from a rare disease by a first-ever personalized gene fix has reached a big milestone, taking his first steps ahead ...

Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Chromosomes are thread-like structures that carry a cell's ...