Histone chaperones also participate in the selective deposition of histone variants, which are functionally distinct from canonical histones. For example, HIRA is a chaperone that specifically deposits the …

A histone is a type of protein that plays a critical role in the structural organization and regulation of DNA within the nucleus of eukaryotic cells.

3 days ago · A histone is a protein that provides structural support for a chromosome. Each chromosome contains a long molecule of DNA, which must fit into the cell nucleus.

Aug 22, 2025 · When DNA is damaged, histone modifications can help make affected DNA regions more accessible to repair enzymes. For example, specific histone modifications can recruit repair …

4 days ago · Ahmad et al. show that soluble histone H4 binds at histone genes and acts as a repressor of their expression. These findings suggest that histone H4 is a sensor of ongoing DNA replication. …

These complex histone modifications constitute the so-called epigenetic histone code, which might play a role in determining and stabilizing gene expression patterns from one generation to the next …

May 4, 2025 · The histone family consists of five main classes: H1 (linker histone) and the core histones H2A, H2B, H3, and H4. Core histones form an octamer composed of two H2A-H2B dimers and one …

histone (HIS-tone) A type of protein found in chromosomes. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes.

Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.

The word "histone" dates from the late 19th century and is from the German "Histon", of uncertain origin: perhaps from Greek histanai or from histos. Until the early 1990s, histones were dismissed as merely …